Arborpointe
Partners

Commercial operations readiness for biopharma,
before the permanent team is in place.

Senior Fractional · Interim · Advisory Commercial Operations Leadership

Ganesh Rajaratnam Founder
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Arrived at commercial operations through commercial FP&A, not despite it.

Computer engineer by training, with a minor in engineering science and mathematics. A decade in corporate finance, FP&A, and investor relations — including writing earnings call scripts, supporting roadshows, and traveling with the C-suite to JPMorgan and other investor conferences. Commercial FP&A leadership across the VIVITROL relaunch and the ARISTADA launch at Alkermes. A year carrying a bag in specialty sales. Director of Sales Operations at AMAG through the VYLEESI launch — running in parallel with the harmonization of three acquired products. Then commercial operations leadership across three launch builds from blank canvas: AVEO/FOTIVDA, Zevra/MIPLYFFA, and Alkeus/ALK-001.

The career arc is the proof. Each step added a dimension that the next required.

computer engineering  →  corporate finance  →  commercial FP&A  →  investor relations  →  field sales  →  sales operations  →  commercial operations

Commercial operations work is a finance problem dressed up as a commercial problem — and the underlying infrastructure is a systems problem. Translating launch strategy into operating expense, FTE timing, and executable systems the board can defend requires someone who has done all three. The engineering foundation shows up in every CDE architecture and forecasting model. The FP&A fluency shows up in every budget conversation. The IR experience shows up in every board-ready document.

I built Arborpointe Partners because emerging biopharma deserves the same rigor in commercial operations planning that clinical and CMC plans already get — and patients only benefit from therapies that actually launch well.

6
Commercial Launches
Across five companies — three as senior commercial operations architect from blank canvas, two as commercial FP&A leader, one as Director of Sales Operations
20+
Years in Biopharma
Spanning engineering, corporate finance, FP&A, investor relations, specialty sales, sales operations, and commercial operations leadership
$10M+
Commercial Operations Budget Managed
With less than 5% variance — vendor governance, SOW management, and P&L discipline throughout

The commercial operations story is often the weakest part of the board deck.

Clinical and CMC plans get built with rigor — costed, sequenced, defensible. Commercial operations is sketched: “we’ll build a team, we’ll launch, we’ll figure it out.” That gap costs companies three ways: boards lose confidence in commercial readiness, capital gets misallocated, and the future commercial team inherits chaos instead of an inheritable foundation.

Three moments in a biopharma’s commercial life require senior operations leadership before — or alongside — a permanent VP/SVP hire:

01   Launch
Pre-launch biopharma

Phase 2 data in hand or imminent. Board pressure on commercial readiness. No CCO yet, or a new CCO scoping the build. The classic Arborpointe engagement — leading commercial operations setup from blank canvas, or scoping the build for an incoming team.

02   Integration / Review
Post-M&A or commercial-stage biopharma

Post-M&A harmonization, or a strategic review of an existing commercial operations function. Multiple products, systems, or field forces to integrate — or an existing architecture that needs assessment ahead of a second product, an expansion, or board scrutiny. The commercial engine has to keep running while the work happens.

03   Strategic Process
Pre-transaction biopharma

CEO with BD/Corp Dev background. Exploring strategic alternatives, partnership, or acquisition. The board needs commercial defensibility for diligence — a story that survives bottoms-up acquirer review, not a strategy deck.

Five buyer states that benefit from senior commercial operations leadership before — or alongside — a permanent senior hire:

  • You have a CCO in place who needs senior surge capacity for a specific build — not a permanent additional hire
  • You’re scoping the eventual permanent commercial ops hire and want an inheritable foundation in place first
  • The board is asking for commercial readiness milestones, and you don’t yet have a senior commercial operations leader to answer
  • You’re exploring strategic alternatives, and your commercial readiness story has to survive bottoms-up acquirer review
  • You’ve completed an acquisition, and your commercial backbone has to absorb a second product, second field force, or second data environment
The Most Distinctive Sentence
“Commercial operations work is a finance problem dressed up as a commercial problem — and the underlying infrastructure is a systems problem. The work Arborpointe does requires someone who has done all three.”

The full commercial
operating backbone.

Commercial Data Environment
CDE architecture, CRM implementation, MDM, data warehouse, BI dashboards, and executive reporting — designed to scale from first launch to second product
Forecasting & GTN
EPI-based demand models, gross-to-net framework, AOP/LRP process, scenario planning, and the P&L discipline that Finance and boards require
Field & Sales Operations
Territory sizing and alignment, incentive compensation design and governance, targeting methodology, field effectiveness analytics, fleet management, and training program scoping and vendor governance
Launch Governance
Cross-functional launch committees, KPI frameworks, risk registers, compliance integration, and board-ready performance reporting
Market Research & CI
ATU studies, patient and HCP primary research, demand studies, competitive landscape tracking, and omnichannel analytics programs
Vendor Ecosystem
Partner selection, SOW negotiation, budget oversight, MSA/SLA management, and governance structures that protect both quality and capital

Commercial operations is the spike.
The work doesn’t stop at its borders.

These are the commercial and financial capabilities I have personally led or carried out in prior roles — not theoretical, not coordinated through someone else. They show up in every commercial operations engagement, and they explain why the work doesn’t fragment when it crosses functional lines.

Sales
Carried · Supported

A year carrying a bag in specialty sales. Supported sales team builds alongside commercial leadership — territory design, deployment planning, and IC governance.

Marketing Operations
Operations Side

Campaign measurement, content workflow governance, vendor management, and ROI analytics. Not marketing strategy — the operating system that runs underneath it.

Market Access Operations
Operations Side

Payer data integration, channel reporting, GTN operations, and specialty distributor analytics. Not payer negotiation — the data and reporting backbone behind it.

Training & Development Ops
Program Governance

Curriculum scoping, vendor selection, certification frameworks, and program governance across sales, market access, and patient services.

Project & Program Management
Hands-On

Detailed Gantt charts, cross-functional sequencing, milestone governance, and risk register management. The discipline that keeps every launch on the rails.

Corporate Finance & FP&A
A Decade

Commercial FP&A leadership across the VIVITROL relaunch and ARISTADA launch at Alkermes. AOP/LRP, scenario planning, and the budget discipline that survives board diligence.

Investor Relations
C-Suite Adjacent

Earnings call script authorship, roadshow support, and C-suite travel to JPMorgan and other investor conferences. The board-ready communication discipline that every CFO recognizes.

Engineering Foundation
Undergraduate

Computer engineering with a minor in engineering science and mathematics. The systems-thinking foundation that shows up in every CDE architecture, every forecasting model, and every data integration.

Every engagement is scoped honestly. When the work extends beyond commercial operations and its adjacencies, I bring in the right partner rather than overclaim.

Built for first launches.
Proven in the field.

Most engagements below were firsts — first launch, first commercial ops build, first data environment from a blank canvas. That is where the work is hardest, the decisions matter most, and the experience is most relevant to what you are building.

Rare Ophthalmology
Alkeus Pharmaceuticals
ALK-001 · Stargardt Disease
Full Commercial Operations, Insights & Analytics build for first-in-class rare retina launch — organizational structure, CDE, CRM, forecasting, GTN, field deployment, IC design, and launch governance from scratch
Ultra-Rare
Zevra Therapeutics
MIPLYFFA® · Niemann-Pick Type C
CDE framework, launch KPI structure, forecasting model, and sales operations governance ahead of FDA approval for ultra-rare neurological disorder
Oncology
AVEO Oncology
FOTIVDA® · Renal Cell Carcinoma
Enterprise CDE, MDM, forecasting, and GTN frameworks built from a blank canvas in under five months — delivering low-single-digit net-revenue forecast accuracy and sub-2% GTN accuracy. ML-driven patient targeting with ipm.ai (Real Chemistry) drove 47% of Q1 new starts
Women's Health
AMAG Pharmaceuticals
VYLEESI® · HSDD
CDE rebuild across three disparate field teams; launch forecasting and early uptake analytics for new product launch in women's health
CNS / Specialty
Alkermes
ARISTADA® · VIVITROL®
Commercial analytics, GTN modeling, IC administration, and payer/trade analytics supporting two flagship specialty launches
Commercial Diligence
Catalyst Pharmaceuticals
Portfolio Expansion Strategy
Commercial due diligence supporting potential portfolio acquisition — treatment paradigm, competitive dynamics, and early infrastructure planning

Direct hands-on experience across oncology, rare disease, neurology, women’s health, and specialty — with particular depth in rare disease and first-in-class launches.

Oncology Rare Disease Rare Retina / Ophthalmology Neurology & CNS Women's Health Specialty Gene Therapy Ultra-Rare

A three-tier engagement ladder.

Each tier flows into the next. Engagements are fractional, interim, or advisory — the format follows the work.

Let's see if there's a fit.

A 30-minute conversation — no slides, no pitch — focused on where the company is, what's been built, and where the commercial readiness gaps actually sit. If there's a fit, a scoping conversation follows. If there isn't, an honest "here's who I'd point you to instead."

Phone 978-944-1800
Location Greater Boston · Hybrid · Remote
Therapeutic Areas
Deep experience leading commercial operations across these categories — with particular depth in rare disease and first-in-class launches.
Oncology Rare Disease Rare Retina / Ophthalmology Neurology & CNS Women's Health Specialty Gene Therapy Ultra-Rare
Pricing
All engagements are custom-scoped. Contact for pricing — rates vary by commitment level, exclusivity, and scope.