Arborpointe Partners · Greater Boston

Ganesh
Rajaratnam

Head of Fractional Commercial Operations  ·  Pre-Commercial Build & First Launch  ·  Oncology & Rare Disease

The commercial ops leader who builds the engine before launch — and knows what to prioritize when time and budget are limited.

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Who I Am

An unconventional path.
A distinct advantage.

Engineer by training. A decade in corporate finance, FP&A, and investor relations. A year carrying a bag in specialty sales. 15+ years building commercial operations infrastructure for first launches.

That unconventional path means I speak the language of every stakeholder — CFO, CCO, field rep, and board. I understand what missing a top-line number means for the full P&L, not just the revenue line. I design reporting that Finance trusts, IC plans that reps respect, and CDE architectures that scale.

I partner with pre-commercial and launch-stage biotechs as an embedded fractional leader — building the commercial backbone from strategy through execution, without the overhead of a full-time VP hire before the organization is ready for one.

20+
Years in Biopharma
Spanning engineering, corporate finance, investor relations, specialty sales, and commercial operations leadership
7
Launches & Pre-Launch Builds
Oncology, rare disease, retina, CNS, neurology, women's health, and specialty across multiple modalities
$10M+
Commercial Operations Budget Managed
With less than 5% variance — vendor governance, SOW management, and P&L discipline throughout

What I Build

The full commercial
operating backbone.

Commercial Data Environment
CDE architecture, CRM implementation, MDM, data warehouse, BI dashboards, and executive reporting — designed to scale from first launch to second product
Forecasting & GTN
EPI-based demand models, gross-to-net framework, AOP/LRP process, scenario planning, and the P&L discipline that Finance and boards require
Field & Sales Operations
Territory sizing and alignment, incentive compensation design and governance, targeting methodology, field effectiveness analytics, and fleet management
Launch Governance
Cross-functional launch committees, KPI frameworks, risk registers, compliance integration, and board-ready performance reporting
Market Research & CI
ATU studies, patient and HCP primary research, demand studies, competitive landscape tracking, and omnichannel analytics programs
Vendor Ecosystem
Partner selection, SOW negotiation, budget oversight, MSA/SLA management, and governance structures that protect both quality and capital

Track Record

Built for first launches.
Proven in the field.

Every engagement below was a first — first launch, first commercial ops build, first data environment from a blank canvas. That is where the work is hardest, the decisions matter most, and the experience is most relevant to what you are building.

Rare Ophthalmology
Alkeus Pharmaceuticals
ALK-001 · Stargardt Disease
Full COIA build for first-in-class rare retina launch — organizational structure, CDE, CRM, forecasting, GTN, field deployment, IC design, and launch governance from scratch
Ultra-Rare
Zevra Therapeutics
MIPLYFFA® · Niemann-Pick Type C
CDE framework, launch KPI structure, forecasting model, and sales operations governance ahead of FDA approval for ultra-rare neurological disorder
Oncology
AVEO Oncology
FOTIVDA® · Renal Cell Carcinoma
Enterprise CDE, MDM, and analytics built from blank canvas in under 5 months; ML-driven patient targeting with ipm.ai (Real Chemistry) drove 47% of Q1 new starts
Commercial Diligence
Catalyst Pharmaceuticals
Portfolio Expansion Strategy
Commercial due diligence supporting potential portfolio acquisition — treatment paradigm, competitive dynamics, and early infrastructure planning
Women's Health
AMAG Pharmaceuticals
VYLEESI® · HSDD
CDE rebuild across three disparate field teams; launch forecasting and early uptake analytics for new product launch in women's health
CNS / Specialty
Alkermes
ARISTADA® · VIVITROL®
Commercial analytics, GTN modeling, IC administration, and payer/trade analytics supporting two flagship specialty launches

How I Work

Three ways to engage.

Get in Touch

Let's talk about
your launch.

If your company is preparing for a first launch in rare disease or specialty — or building the commercial infrastructure to get there — I'd welcome a conversation about how I can help.

Email ganesh@arborpointepartners.com
Phone 978-944-1800
LinkedIn linkedin.com/in/ganeshrajaratnam
Location Greater Boston · Available Remotely
Therapeutic Areas
Deep experience building commercial infrastructure across these categories — with particular depth in rare disease and first-in-class launches.
Oncology Rare Disease Rare Retina / Ophthalmology Neurology & CNS Women's Health Specialty Gene Therapy Ultra-Rare
Pricing
All engagements are custom-scoped. Contact for pricing — rates vary by commitment level, exclusivity, and scope.